Heterotrimeric G protein activation by G-protein-coupled receptors.

Oldham WM, Hamm HE
Nat Rev Mol Cell Biol. 2008 9 (1): 60-71

PMID: 18043707 · DOI:10.1038/nrm2299

Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the plasma membrane.

MeSH Terms (8)

Animals Cell Membrane Heterotrimeric GTP-Binding Proteins Humans Protein Binding Protein Conformation Receptors, G-Protein-Coupled Signal Transduction

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