Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.

Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH
J Clin Invest. 2007 117 (12): 3810-20

PMID: 18037992 · PMCID: PMC2082142 · DOI:10.1172/JCI30487

MeSH Terms (20)

Animals Calcium-Binding Proteins Cell Hypoxia Cell Movement Chronic Disease Collagen Epithelial Cells Extracellular Matrix Fibrosis Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit Kidney Tubules, Proximal Mice Mice, Knockout Protein-Lysine 6-Oxidase S100 Calcium-Binding Protein A4 S100 Proteins Signal Transduction Up-Regulation Ureteral Obstruction

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