Family history of cancer and risk of lung cancer among nonsmoking Chinese women.

Zhang Y, Shu XO, Gao YT, Ji BT, Yang G, Li HL, Kilfoy B, Rothman N, Zheng W, Chow WH
Cancer Epidemiol Biomarkers Prev. 2007 16 (11): 2432-5

PMID: 18006933 · DOI:10.1158/1055-9965.EPI-07-0398

The relationship between family cancer history in first-degree relatives and risk of lung cancer was evaluated among a population-based cohort of 71,392 female nonsmokers in Shanghai, China. A total of 179 newly diagnosed lung cancer patients were identified during 441,410 person-years of follow-up. Lung cancer risk was not elevated among those with a family history of lung cancer. However, risk of lung cancer was increased among subjects who had two or more first-degree relatives with any type of cancers {rate ratio [RR], 1.95 [95% confidence intervals (95% CI), 1.08-3.54] for two relatives with any cancers and RR, 3.17 [95% CI, 1.00-10.03] for three or more relatives with any cancer}. Having a family history of colorectal cancer (RR, 2.38; 95% CI, 1.21-4.70) and having siblings with stomach cancer (RR, 2.16; 95% CI, 1.01-4.65) and pancreatic cancer (RR, 4.19; 95% CI, 1.04-16.95) were also found to be associated with lung cancer risk. This cohort study indicated a moderate association of lung cancer risk with a family cancer history in general, but not with a family history of lung cancer specifically. The associations were stronger when a sibling, rather than a parent, was affected. The apparent link between lung cancer risk and a family history of colorectal, stomach, and pancreas cancers may be worth further investigation.

MeSH Terms (12)

Adult Aged China Cohort Studies Family Health Female Genetic Predisposition to Disease Humans Lung Neoplasms Middle Aged Neoplasms Smoking

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