The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.

Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK
Genes Dev. 2007 21 (21): 2788-803

PMID: 17974918 · PMCID: PMC2045132 · DOI:10.1101/gad.1544507

MeSH Terms (18)

Animals Cell Transformation, Neoplastic Epithelial Cells Esophageal Neoplasms Esophagus Female Gene Expression Regulation, Neoplastic Genes, erbB-1 Genes, p53 Humans Mice Mice, Nude Mutation Neoplasm Invasiveness Neoplasms, Squamous Cell Stromal Cells Telomerase Tumor Cells, Cultured

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