Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
Nat Med. 2007 13 (10): 1193-202

PMID: 17906635 · DOI:10.1038/nm1662

MeSH Terms (25)

Acetyltransferases Animals Body Weight Carcinoma, Hepatocellular Cell Line, Tumor Diet, Atherogenic Dietary Fats Fatty Acid Elongases Gene Deletion Insulin Insulin Receptor Substrate Proteins Insulin Resistance Intracellular Signaling Peptides and Proteins Liver Neoplasms Male Mice Mice, Knockout Obesity Phosphoproteins Phosphorylation Protein Kinase C-epsilon Proto-Oncogene Proteins c-akt RNA, Messenger Signal Transduction Time Factors

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