MALDI imaging mass spectrometry: molecular snapshots of biochemical systems.

Cornett DS, Reyzer ML, Chaurand P, Caprioli RM
Nat Methods. 2007 4 (10): 828-33

PMID: 17901873 · DOI:10.1038/nmeth1094

Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is emerging as a powerful tool for investigating the distribution of molecules within biological systems through the direct analysis of thin tissue sections. Unique among imaging methods, MALDI-IMS can determine the distribution of hundreds of unknown compounds in a single measurement. We discuss the current state of the art of MALDI-IMS along with some recent applications and technological developments that illustrate not only its current capabilities but also the future potential of the technique to provide a better understanding of the underlying molecular mechanisms of biological processes.

MeSH Terms (7)

Animals Developmental Biology Pathology Pharmaceutical Preparations Phospholipids Proteomics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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