Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.

Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M
Nucleic Acids Res. 2007 35 (19): 6424-38

PMID: 17881374 · PMCID: PMC2095806 · DOI:10.1093/nar/gkm664

MeSH Terms (18)

Argonaute Proteins Base Pairing Base Pair Mismatch Crystallography, X-Ray Eukaryotic Initiation Factor-2 Fluorobenzenes HeLa Cells Humans Hydrogen Bonding Models, Molecular Nucleotides Oligoribonucleotides Osmotic Pressure RNA, Small Interfering RNA-Induced Silencing Complex RNA Interference Substrate Specificity Thermodynamics

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