Regulation of angiogenesis and vascular permeability by Src family kinases: opportunities for therapeutic treatment of solid tumors.

Park SI, Shah AN, Zhang J, Gallick GE
Expert Opin Ther Targets. 2007 11 (9): 1207-17

PMID: 17845146 · DOI:10.1517/14728222.11.9.1207

Aberrant expression or activation of protein tyrosine kinases, including Src and related Src family kinases, is a common occurrence in many human cancers, resulting in deregulation of expression of numerous mediators of cellular functions, including pro-angiogenic molecules. In addition, Src activation regulates vascular permeability of endothelial cells. How these processes contribute to tumor progression and metastasis are the subjects of this review. As Src-selective inhibitors have entered clinical trials for a number of solid tumors, further understanding of the roles of Src kinases in mediating tumor angiogenesis as well as modulating tumor/microenvironment interactions will provide insights into the best use of these inhibitors in treating patients afflicted with tumors in which Src is activated.

MeSH Terms (8)

Animals Capillary Permeability Endothelial Cells Humans Neoplasms Neovascularization, Pathologic src-Family Kinases Vascular Endothelial Growth Factor A

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