Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal.

Frøhlich RF, Veigaard C, Andersen FF, McClendon AK, Gentry AC, Andersen AH, Osheroff N, Stevnsner T, Knudsen BR
Nucleic Acids Res. 2007 35 (18): 6170-80

PMID: 17827209 · PMCID: PMC2094083 · DOI:10.1093/nar/gkm669

MeSH Terms (9)

Camptothecin DNA, Superhelical DNA Topoisomerases, Type I Enzyme Inhibitors Humans Kinetics Mutation Plasmids Tryptophan

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