The orexins/hypocretins and schizophrenia.

Deutch AY, Bubser M
Schizophr Bull. 2007 33 (6): 1277-83

PMID: 17728265 · PMCID: PMC2779882 · DOI:10.1093/schbul/sbm096

Advances in molecular biology have led to new peptides and proteins being discovered on a regular basis, including the isolation of a number of neurotransmitter candidates. Rarely, however, do these immediately capture the attention of the scientific community. The isolation and characterization of the orexin/hypocretin peptides a decade ago resulted in a slew of studies that have helped clarified their diverse functions, including prominent roles in arousal and appetitive behavior. A number of recent studies have detailed the role of the orexins/hypocretins in attention and cognition and uncovered an involvement in schizophrenia and the mechanisms of action of antipsychotic drugs (APDs). This issue of Schizophrenia Bulletin presents several articles that review our current understanding and point to future directions for the study of the orexins/hypocretins in schizophrenia and APD actions.

MeSH Terms (10)

Benzhydryl Compounds Brain Central Nervous System Stimulants Chromosomes, Human, Pair 17 Humans Intracellular Signaling Peptides and Proteins Modafinil Neuropeptides Orexins Schizophrenia

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