Progress toward antibody-induced transplantation tolerance.

Moore DJ, Kim JI, Sonawane S, Yeh H, Deng S, Lee K, Markmann JF
Crit Rev Immunol. 2007 27 (2): 167-218

PMID: 17725502 · DOI:10.1615/critrevimmunol.v27.i2.40

Transplantation tolerance remains an elusive goal. Despite multiple animal models of tolerance induction using a variety of agents and protocols, it has yet to be achieved in humans with any predictability. In this review, we examine some of the antibodies directed toward T cells that show promise in prolonging graft survival in animal models and in preliminary clinical assessment. Because these antibodies work through multiple pathways, including depletion, downregulation, receptor-ligand blockade, and direct signaling, they have also helped us tease out the various components of long-lived donor-specific tolerance. In particular, we review the role of the thymus in therapies targeted at the peripheral immune system; the importance of the thymus in tolerance induced by anti-CD45RB suggests that central tolerance mechanisms may be more important than previously appreciated.

MeSH Terms (5)

Animals Antibodies Graft Rejection Humans Transplantation Tolerance

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