, a bio/informatics shared resource is still "open for business" - Visit the CDS website

Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients.

Himmelfarb J, Phinney S, Ikizler TA, Kane J, McMonagle E, Miller G
J Ren Nutr. 2007 17 (5): 296-304

PMID: 17720098 · DOI:10.1053/j.jrn.2007.05.011

OBJECTIVE - Increased cardiovascular risk in hemodialysis patients may be related to augmented oxidative stress and inflammation, for which no proven beneficial therapies are available.

STUDY DESIGN - We examined the effects of gamma tocopherol and docosahexaenoic acid (DHA) administration on inflammation and oxidative stress markers in hemodialysis patients in a randomized, double-blinded, placebo-controlled, clinical trial. Active treatment consisted of capsules containing gamma tocopherol (308 mg) and DHA (800 mg).

SETTING - Outpatient dialysis center.

PATIENTS - Seventy maintenance hemodialysis patients.

MAIN OUTCOME MEASURES - Plasma concentrations of interleukin-6 (IL-6) and protein carbonyl content were determined by enzyme-linked immunosorbant assay. C-reactive protein was measured by nephelometry. The F(2) isoprostanes were measured by gas chromatography-mass spectrometry. Erythrocyte DHA content was measured by gas chromatography.

RESULTS - Sixty-three patients were enrolled, and 57 completed the study. No serious adverse events were attributed to either active treatment or placebo. In the treatment group, but not in the placebo group, there were significant decreases in IL-6 (21.4 +/- 3.5 to 16.8 +/- 3.7 pg/mL), white blood cell (WBC) count (7.4 +/- 0.3 to 6.9 +/- 0.4 10(3)/microL), and neutrophil fraction of WBCs (4.8 +/- 0.3 to 4.4 +/- 0.3 10(3)/microL), at P < .05 for all. There were no significant changes in plasma concentrations of CRP, F(2) isoprostanes, or carbonyls in either group.

CONCLUSION - Thus, gamma tocopherol and DHA are well-tolerated and reduce selected biomarkers of inflammation in hemodialysis patients. Larger randomized, clinical trials will be required to determine if gamma tocopherol and DHA can reduce cardiovascular complications in hemodialysis patients.

MeSH Terms (25)

Adult Aged Biomarkers C-Reactive Protein Chromatography, Gas Dietary Supplements Docosahexaenoic Acids Double-Blind Method Enzyme-Linked Immunosorbent Assay Erythrocytes F2-Isoprostanes Female gamma-Tocopherol Gas Chromatography-Mass Spectrometry Humans Inflammation Interleukin-6 Kidney Failure, Chronic Male Middle Aged Nephelometry and Turbidimetry Oxidative Stress Protein Carbonylation Renal Dialysis Treatment Outcome

Connections (1)

This publication is referenced by other Labnodes entities: