EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses.

Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB
Nat Neurosci. 2007 10 (9): 1131-3

PMID: 17676060 · DOI:10.1038/nn1949

Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.

MeSH Terms (14)

Animals Body Temperature Dinoprostone Fever Gene Expression Regulation Green Fluorescent Proteins In Situ Hybridization Mice Mice, Knockout Neurons Preoptic Area Receptors, Prostaglandin E Receptors, Prostaglandin E, EP3 Subtype Time Factors

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