Asthma is associated with increased mortality in individuals with sickle cell anemia.

Boyd JH, Macklin EA, Strunk RC, DeBaun MR
Haematologica. 2007 92 (8): 1115-8

PMID: 17650441 · DOI:10.3324/haematol.11213

An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled from birth through adulthood, was conducted to determine if asthma is a risk factor for death in SCA. All-cause mortality was determined for participants after adjusting for known risk factors for death in SCA. The study included 1,963 individuals who were followed for 18,495 patient-years. After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA.

MeSH Terms (26)

Acute Disease Adolescent Adult African Americans Anemia, Sickle Cell Asthma Cause of Death Chest Pain Child Child, Preschool Cohort Studies Comorbidity Female Follow-Up Studies Humans Infant Infant, Newborn Kaplan-Meier Estimate Male Middle Aged Proportional Hazards Models Prospective Studies Renal Insufficiency Risk Factors Seizures Survival Analysis

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