Transcriptional oncogenomic hot spots in Barrett's adenocarcinomas: serial analysis of gene expression.

Razvi MH, Peng D, Dar AA, Powell SM, Frierson HF, Moskaluk CA, Washington K, El-Rifai W
Genes Chromosomes Cancer. 2007 46 (10): 914-28

PMID: 17636545 · DOI:10.1002/gcc.20479

Serial analysis of gene expression (SAGE) provides quantitative and comprehensive expression profiling in a given cell population. In our efforts to define gene expression alterations in Barrett's-related adenocarcinomas (BA), we produced eight SAGE libraries and obtained a total of 457,894 expressed tags with 32,035 (6.9%) accounting for singleton tags. The tumor samples produced an average of 71,804 tags per library, whereas normal samples produced an average of 42,669 tags per library. Our libraries contained 67,200 unique tags representing 16,040 known gene symbols. Five hundred and sixty-eight unique tags were differentially expressed between BAs and normal tissue samples (at least twofold; P
Copyright (c) 2007 Wiley-Liss, Inc.

MeSH Terms (20)

Adenocarcinoma Barrett Esophagus Biomarkers, Tumor CD13 Antigens Esophageal Neoplasms Expressed Sequence Tags Female Gastric Mucosa Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Library Humans Immunoenzyme Techniques Intestinal Neoplasms Male Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Tissue Array Analysis Transcription, Genetic Tumor Cells, Cultured

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