Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn.

Anilakumar KR, Nagaraj NS, Santhanam K
Indian J Exp Biol. 2007 45 (5): 450-4

PMID: 17569287

The effect of prefeeding of dehydrated E. officinalis (amla) powder at 5 and 10% levels on hexachlorocyclohexane (HCH)-induced changes in multicomponent antioxidant system and lipid peroxides in rat liver was studied. HCH induced significant elevation in hepatic malondialdehyde, conjugated dienes and hydroperoxides. The prefeeding of amla at 10% level could decrease the formation of these lipid peroxides significantly. The HCH abuse resulted in a significant reduction in hepatic glutathione S-transferase (GST), glucose-6-phosphate dehydrogenase (G-6-PDH) and superoxide dismutase (SOD) activities with an elevation in the activities of glutathione peroxidase and gamma-glutamyl transpeptidase (GGT). On the other hand, the HCH-induced impairment in hepatic catalase, G-6-PDH and SOD activities were modulated by amla at the 10% level of intake. Prefeeding of amla at 5 and 10% levels appeared to reduce the HCH-induced raise in renal GGT activity. The results show the elevation of hepatic antioxidant system and reduction of cytotoxic products as a result of prefeeding of amla, which were otherwise affected by the HCH administration.

MeSH Terms (20)

Animals Antioxidants Chemical and Drug Induced Liver Injury Cytoprotection Eating gamma-Glutamyltransferase Hexachlorocyclohexane Kidney Lipid Peroxidation Liver Liver Diseases Male Organ Size Oxidative Stress Phyllanthus emblica Phytotherapy Plant Extracts Rats Rats, Wistar Weight Gain

Connections (1)

This publication is referenced by other Labnodes entities: