The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL
J Clin Invest. 2007 117 (6): 1616-26

PMID: 17549257 · PMCID: PMC1878533 · DOI:10.1172/JCI31581

MeSH Terms (15)

Animals Basic Helix-Loop-Helix Transcription Factors Bone Development Cells, Cultured Gene Expression Hypoxia-Inducible Factor 1, alpha Subunit Mice Mice, Knockout Models, Biological Neovascularization, Physiologic Osteoblasts Osteogenesis Signal Transduction Vascular Endothelial Growth Factor A Von Hippel-Lindau Tumor Suppressor Protein

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