A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart study.

Wagenknecht LE, Langefeld CD, Freedman BI, Carr JJ, Bowden DW
Am J Epidemiol. 2007 166 (3): 340-7

PMID: 17493948 · PMCID: PMC4450101 · DOI:10.1093/aje/kwm091

The extent of shared risk factors for calcified atherosclerotic plaque (CAP) of the coronary, carotid, and abdominal aortic arteries is unknown. CAP was measured by computed tomography in 1,125 individuals in families affected with diabetes. Statistical methods adjusted for the lack of independence between observations. CAP scores were standardized, and tests of interaction were conducted to compare risk factor relations across vascular beds. The average age of the cohort was 61 years, and 84% had diabetes. The correlation in CAP scores across vascular beds ranged from 0.59 to 0.72. Age, albumin/creatinine ratio, hemoglobin A1c, diabetes, hypertension, and lipid-lowering therapy were correlated with quantity of CAP in all vascular beds (all p<0.05); no differences in the strength of these relations were noted. In contrast, other significant correlates differed in the strength of their relations with CAP. The risk factor pack-years of smoking was most strongly correlated with CAP in the abdominal aorta (p<0.005). Male gender, previous myocardial infarction, and coronary revascularization were most strongly correlated with CAP in the coronary arteries (p<0.0001). In summary, CAPs of the coronary, carotid, and abdominal aortic arteries generally share common risk factors, even though several of these factors have a greater impact on CAP in one vascular bed than another.

MeSH Terms (18)

African Americans Aged Aorta, Abdominal Aortic Diseases Calcinosis Carotid Artery Diseases Coronary Artery Disease Diabetes Mellitus, Type 2 European Continental Ancestry Group Female Humans Male Middle Aged North Carolina Risk Factors Sex Factors Time Factors Tomography, X-Ray Computed

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