Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission.

Wijayawardhane N, Shonesy BC, Vaglenova J, Vaithianathan T, Carpenter M, Breese CR, Dityatev A, Suppiramaniam V
Neurobiol Dis. 2007 26 (3): 696-706

PMID: 17493826 · DOI:10.1016/j.nbd.2007.03.009

Aniracetam is a nootropic compound and an allosteric modulator of AMPA receptors (AMPARs) which mediate synaptic mechanisms of learning and memory. Here we analyzed impairments in AMPAR-mediated synaptic transmission caused by moderate prenatal ethanol exposure and investigated the effects of postnatal aniracetam treatment on these abnormalities. Pregnant Sprague-Dawley rats were gavaged with ethanol or isocaloric sucrose throughout pregnancy, and subsequently the offspring were treated with aniracetam on postnatal days (PND) 18 to 27. Hippocampal slices prepared from these pups on PND 28 to 34 were used for the whole-cell patch-clamp recordings of AMPAR-mediated spontaneous and miniature excitatory postsynaptic currents in CA1 pyramidal cells. Our results indicate that moderate ethanol exposure during pregnancy results in impaired hippocampal AMPAR-mediated neurotransmission, and critically timed aniracetam treatment can abrogate this deficiency. These results highlight the possibility that aniracetam treatment can restore synaptic transmission and ameliorate cognitive deficits associated with the fetal alcohol syndrome.

MeSH Terms (22)

Alcohol-Induced Disorders, Nervous System Animals Animals, Newborn Central Nervous System Depressants Ethanol Female Glutamic Acid Hippocampus Male Neural Pathways Nootropic Agents Organ Culture Techniques Patch-Clamp Techniques Pregnancy Prenatal Exposure Delayed Effects Pyramidal Cells Pyrrolidinones Rats Rats, Sprague-Dawley Receptors, AMPA Synaptic Transmission Treatment Outcome

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