Cutting edge: transplant tolerance induced by anti-CD45RB requires B lymphocytes.

Deng S, Moore DJ, Huang X, Lian MM, Mohiuddin M, Velededeoglu E, Lee MK, Sonawane S, Kim J, Wang J, Chen H, Corfe SA, Paige C, Shlomchik M, Caton A, Markmann JF
J Immunol. 2007 178 (10): 6028-32

PMID: 17475825 · DOI:10.4049/jimmunol.178.10.6028

Selective interference with the CD45RB isoform by mAb (anti-CD45RB) reliably induces donor-specific tolerance. Although previous studies suggest participation of regulatory T cells, a mechanistic understanding of anti-CD45RB-induced tolerance is lacking. We report herein the unexpected finding that tolerance induced by this agent is not established in B cell-deficient mice but can be recovered by preemptive B lymphocyte transfer to B cell-deficient hosts. Using B cells from genetically modified donors to reconstitute B cell-deficient recipients, we evaluate the role of B lymphocyte-expressed CD45RB, T cell costimulatory molecules, and the production of Abs in this novel tolerance mechanism. Our data document an Ab-induced tolerance regimen that is uniquely B lymphocyte-dependent and suggest mechanistic contributions to tolerance development from the B cell compartment through interactions with T cells.

MeSH Terms (16)

Animals Antibodies, Monoclonal B-Lymphocyte Subsets Cell Communication Cell Proliferation Heart Transplantation Immunophenotyping Leukocyte Common Antigens Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Mice, Transgenic T-Lymphocytes, Regulatory Transplantation Tolerance

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