Gastrointestinal complications associated with hepatic arterial Yttrium-90 microsphere therapy.

Murthy R, Brown DB, Salem R, Meranze SG, Coldwell DM, Krishnan S, Nunez R, Habbu A, Liu D, Ross W, Cohen AM, Censullo M
J Vasc Interv Radiol. 2007 18 (4): 553-61; quiz 562

PMID: 17446547 · DOI:10.1016/j.jvir.2007.02.002

Hepatic arterial therapy with yttrium-90 microspheres exploits the avenue provided by the neoplastic microvasculature to deliver high-energy, low-penetrating therapeutic doses of radiation. Variant hepatic arterial anatomy, collateral vessels, and changes in flow dynamics during treatment can affect particle dispersion and lead to nontarget particle distribution and subsequent gastrointestinal morbidity. Awareness of these variances and techniques to prevent gastrointestinal tract microsphere delivery is essential in mitigating this serious complication. Our aim is to increase the understanding of the role of various imaging and preventative techniques in minimizing this undesired effect.

MeSH Terms (19)

Adenocarcinoma Adult Aged Brachytherapy Embolization, Therapeutic Gastrointestinal Tract Hepatic Artery Humans Injections, Intra-Arterial Liver Neoplasms Male Microspheres Peptic Ulcer Peptic Ulcer Hemorrhage Radionuclide Imaging Radiopharmaceuticals Retrospective Studies Technetium Tc 99m Aggregated Albumin Yttrium Radioisotopes

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