Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy.

Dwyer JP, Yates KM, Sumner EL, Stone WJ, Wang Y, Koury MJ, Fogo AB, Zent R
Clin Nephrol. 2007 67 (3): 176-81

PMID: 17390742 · DOI:10.5414/cnp67176

There is no known clinical association between chronic myelogenous leukemia (CML) and membranoproliferative glomerulonephritis (MPGN). We present a patient who was followed in the renal clinic for proteinuria of unknown etiology (3.2 g/24 h) and normal renal function who was diagnosed with CML as well as MPGN and acute renal failure at the same time. The patient's renal function and proteinuria improved when his CML was treated with imatinib mesylate, suggesting that CML either caused or exacerbated existing MGPN. To the best of our knowledge, this is the first reported case of MPGN associated with CML that improved with imatinib mesylate therapy.

MeSH Terms (18)

Benzamides Biopsy Bone Marrow Disease Progression Follow-Up Studies Glomerular Basement Membrane Glomerulonephritis, Membranoproliferative Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive Male Mesangial Cells Microscopy, Electron Middle Aged Piperazines Protein-Tyrosine Kinases Protein Kinase Inhibitors Pyrimidines

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