Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.

Bowman AB, Lam YC, Jafar-Nejad P, Chen HK, Richman R, Samaco RC, Fryer JD, Kahle JJ, Orr HT, Zoghbi HY
Nat Genet. 2007 39 (3): 373-9

PMID: 17322884 · DOI:10.1038/ng1977

MeSH Terms (20)

Animals Ataxin-1 Ataxins Cells, Cultured Cerebellum DNA Repeat Expansion Embryonic Stem Cells Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Models, Biological Models, Genetic Molecular Sequence Data Nerve Tissue Proteins Nuclear Proteins Peptides Purkinje Cells Repressor Proteins Spinocerebellar Ataxias

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