Matrix metalloproteinases and the regulation of tissue remodelling.

Page-McCaw A, Ewald AJ, Werb Z
Nat Rev Mol Cell Biol. 2007 8 (3): 221-33

PMID: 17318226 · PMCID: PMC2760082 · DOI:10.1038/nrm2125

Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

MeSH Terms (13)

Adaptation, Physiological Animals Blood Vessels Bone and Bones Bone Remodeling Embryonic Development Humans Immunity, Innate Inflammation Mammary Glands, Animal Matrix Metalloproteinases Mutation Wound Healing

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