Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ
Mol Pharmacol. 2007 71 (5): 1389-98

PMID: 17303702 · DOI:10.1124/mol.106.032425

MeSH Terms (22)

Allosteric Regulation Allosteric Site Animals Benzamides Binding, Competitive Cell Line Drug Synergism Glycine Humans Male Mutation Neurons Pyrazoles Pyridines Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Resorcinols Substantia Nigra Substrate Specificity Subthalamic Nucleus

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