Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase.

Nazarewicz RR, Zenebe WJ, Parihar A, Larson SK, Alidema E, Choi J, Ghafourifar P
Cancer Res. 2007 67 (3): 1282-90

PMID: 17283165 · DOI:10.1158/0008-5472.CAN-06-3099

MeSH Terms (19)

Animals Antineoplastic Agents, Hormonal Apoptosis Breast Neoplasms Calcium Cell Line, Tumor Cytochromes c Female Humans Lipid Peroxidation Mitochondria Mitochondria, Liver Nitric Oxide Synthase Oxidative Stress Oxygen Consumption Peroxynitrous Acid Rats Rats, Sprague-Dawley Tamoxifen

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