Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW
J Med Chem. 2007 50 (4): 641-62

PMID: 17256834 · DOI:10.1021/jm061152t

MeSH Terms (17)

Animals Antineoplastic Agents bcl-X Protein Biphenyl Compounds Cell Line, Tumor Drug Screening Assays, Antitumor Humans Lymphoma Mice Mice, SCID Models, Molecular Nitrophenols Piperazines Proto-Oncogene Proteins c-bcl-2 Structure-Activity Relationship Sulfonamides Transplantation, Heterologous

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