Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells.

Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, Aburatani H, Akiyama T, Peek RM, Azuma T, Hatakeyama M
Oncogene. 2007 26 (32): 4617-26

PMID: 17237808 · DOI:10.1038/sj.onc.1210251

MeSH Terms (22)

Adenocarcinoma Antigens, Bacterial Bacterial Proteins beta Catenin Cadherins Cell Line Cell Nucleus Cell Transformation, Neoplastic Cyclin-Dependent Kinase Inhibitor p21 Cytoplasm Gastric Mucosa Gene Expression Regulation, Neoplastic Homeodomain Proteins Humans Intestinal Mucosa Mucin-2 Mucins Phosphorylation Precancerous Conditions Stomach Neoplasms Transcriptional Activation Tyrosine

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