Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).

Cobb BS, Payne DM, Reynolds AB, Parsons JT
Mol Cell Biol. 1991 11 (12): 5832-8

PMID: 1719372 · PMCID: PMC361728 · DOI:10.1128/mcb.11.12.5832-5838.1991

MeSH Terms (12)

Amino Acid Sequence Animals Cell Transformation, Neoplastic Chick Embryo Enzyme Activation Molecular Sequence Data Mutation Phosphorylation Precipitin Tests Protein-Tyrosine Kinases Protein Conformation Proto-Oncogene Proteins pp60(c-src)

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