ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.

Lam YC, Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY
Cell. 2006 127 (7): 1335-47

PMID: 17190598 · DOI:10.1016/j.cell.2006.11.038

MeSH Terms (22)

Amino Acid Sequence Animals Animals, Genetically Modified Ataxin-1 Ataxins Brain Cerebellum Conserved Sequence Drosophila Eye Abnormalities Humans Mice Molecular Sequence Data Mutation Nerve Tissue Proteins Nuclear Proteins Peptides Repressor Proteins Sequence Homology, Amino Acid Spinocerebellar Ataxias Transcription, Genetic Wings, Animal

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