Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients.

Pupim LB, Flakoll PJ, Ikizler TA
Eur J Clin Nutr. 2007 61 (5): 686-9

PMID: 17180156 · DOI:10.1038/sj.ejcn.1602578

OBJECTIVE - To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone.

DESIGN - Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin.

SETTING - General Clinical Research Center at Vanderbilt University Medical Center.

SUBJECTS - Five chronic hemodialysis (CHD) patients.

INTERVENTIONS - Intra-dialytic parenteral nutrition (IDPN) with or without exercise.

RESULTS - Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2+/-3.1% per day versus 17.7+/-1.9% per day, P<0.05).

CONCLUSION - Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients.

MeSH Terms (14)

Albumins Caproates Carbon Isotopes Cross-Over Studies Exercise Female Humans Kidney Failure, Chronic Leucine Male Middle Aged Parenteral Nutrition Renal Dialysis Serum Albumin

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