OBJECTIVE - To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone.
DESIGN - Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin.
SETTING - General Clinical Research Center at Vanderbilt University Medical Center.
SUBJECTS - Five chronic hemodialysis (CHD) patients.
INTERVENTIONS - Intra-dialytic parenteral nutrition (IDPN) with or without exercise.
RESULTS - Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2+/-3.1% per day versus 17.7+/-1.9% per day, P<0.05).
CONCLUSION - Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients.