The association between body size, prostate volume and prostate-specific antigen.

Fowke JH, Motley SS, Cookson MS, Concepcion R, Chang SS, Wills ML, Smith JA
Prostate Cancer Prostatic Dis. 2007 10 (2): 137-42

PMID: 17179979 · DOI:10.1038/sj.pcan.4500924

Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We investigated the association between obesity and prostate volume, prostate-specific antigen (PSA) and PSA density among 753 men referred for prostate biopsy. Among men with a negative biopsy, prostate volume significantly increased approximately 25% from the lowest to highest body mass index (BMI), waist or hip circumference or height categories. PSA was 0.7 ng/ml lower with a high waist-to-hip ratio. These associations were less consistent among subjects diagnosed with high-grade prostatic intraepithelial neoplasia or cancer. Our data suggest that obesity and height are independently associated with prostate volume..

MeSH Terms (13)

Abdomen Adult Aged Aged, 80 and over Body Mass Index Body Size Humans Male Middle Aged Prostate Prostate-Specific Antigen Prostatic Hyperplasia Waist-Hip Ratio

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