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Short-term results under three different immunosuppressive regimens at one center.

Schaefer HM, Kizilisik AT, Feurer I, Nylander WA, Langone AJ, Helderman JH, Shaffer D
Transplant Proc. 2006 38 (10): 3466-7

PMID: 17175305 · DOI:10.1016/j.transproceed.2006.10.098

We examined short-term outcomes and posttransplant medical complications under three different immunosuppressive regimens at a single center. The study design was a randomized, prospective, open-label trial comparing a calcineurin inhibitor-free (CNI) protocol to standard triple therapy with tacrolimus, prednisone, and mycophenolate mofetil. They were also compared to a concurrent but nonrandomized third cohort treated with a prednisone-free protocol. All three groups had excellent early outcomes with no significant difference in patient or graft survival or biopsy-proven acute rejection. Serum creatinine was significantly lower in the CNI-free recipients. Lipid panels and posttransplant diabetes mellitus were significantly lower in the prednisone-free patients. Prednisone-free kidney transplant recipients have improved early glucose metabolism and hyperlipidemia compared to CNI-free or standard triple therapy recipients with comparable rejection and graft survival rates.

MeSH Terms (17)

Adrenal Cortex Hormones Biopsy Creatinine Drug Therapy, Combination Graft Rejection Graft Survival Histocompatibility Testing Humans Immunosuppressive Agents Kidney Transplantation Living Donors Methylprednisolone Mycophenolic Acid Prednisone Sirolimus Survival Analysis Treatment Outcome

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