Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.

Sun HD, Malabunga M, Tonra JR, DiRenzo R, Carrick FE, Zheng H, Berthoud HR, McGuinness OP, Shen J, Bohlen P, Leibel RL, Kussie P
Am J Physiol Endocrinol Metab. 2007 292 (3): E964-76

PMID: 17132826 · DOI:10.1152/ajpendo.00089.2006

MeSH Terms (17)

Animals Antibodies, Monoclonal Antibody Specificity Body Composition Central Nervous System Eating Energy Metabolism Female Macaca fascicularis Male Mice Mice, Inbred C57BL Protein Isoforms Rats Rats, Sprague-Dawley Receptor, Fibroblast Growth Factor, Type 1 Weight Loss

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