Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.

Gao L, Wang J, Sekhar KR, Yin H, Yared NF, Schneider SN, Sasi S, Dalton TP, Anderson ME, Chan JY, Morrow JD, Freeman ML
J Biol Chem. 2007 282 (4): 2529-37

PMID: 17127771 · DOI:10.1074/jbc.M607622200

MeSH Terms (16)

Animals Cell Cycle Proteins Cell Line Cullin Proteins Fatty Acids, Omega-3 Gene Expression Regulation Genes, Reporter Humans Intracellular Signaling Peptides and Proteins Kelch-Like ECH-Associated Protein 1 Mice Molecular Structure NF-E2-Related Factor 2 Oxidation-Reduction Oxidative Stress Transcriptional Activation

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