Improved postoperative outcomes associated with preoperative statin therapy.

Hindler K, Shaw AD, Samuels J, Fulton S, Collard CD, Riedel B
Anesthesiology. 2006 105 (6): 1260-72; quiz 1289-90

PMID: 17122590 · DOI:10.1097/00000542-200612000-00027

Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients undergoing cardiac, vascular, or noncardiovascular surgery. Two independent authors abstracted data from 12 retrospective and 3 prospective trials (n = 223,010 patients). A meta-analysis was performed to evaluate the overall effect of preoperative statin therapy on postoperative outcomes. Preoperative statin therapy was associated with 38% and 59% reduction in the risk of mortality after cardiac (1.9% vs. 3.1%; P = 0.0001) and vascular (1.7% vs. 6.1%; P = 0.0001) surgery, respectively. When including noncardiac surgery, a 44% reduction in mortality (2.2% vs. 3.2%; P = 0.0001) was observed. Preoperative statin therapy may reduce postoperative mortality in patients undergoing surgical procedures. However, the statin associated effects on postoperative cardiovascular morbidity are too variable to draw any conclusion.

MeSH Terms (12)

Animals Cardiac Surgical Procedures Cardiotonic Agents Data Interpretation, Statistical Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Prospective Studies Randomized Controlled Trials as Topic Retrospective Studies Surgical Procedures, Operative Treatment Outcome Vascular Surgical Procedures

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