Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia.

Hulbert ML, Scothorn DJ, Panepinto JA, Scott JP, Buchanan GR, Sarnaik S, Fallon R, Chu JY, Wang W, Casella JF, Resar L, Berman B, Adamkiewicz T, Hsu LL, Smith-Whitley K, Mahoney D, Woods G, Watanabe M, DeBaun MR
J Pediatr. 2006 149 (5): 710-2

PMID: 17095350 · DOI:10.1016/j.jpeds.2006.06.037

A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion.

MeSH Terms (18)

Adolescent Anemia, Sickle Cell Blood Transfusion Child Child, Preschool Disease-Free Survival Exchange Transfusion, Whole Blood Female Follow-Up Studies Humans Infant Male Recurrence Retrospective Studies Risk Assessment Risk Factors Stroke Time Factors

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