Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis.

Drake WP, Dhason MS, Nadaf M, Shepherd BE, Vadivelu S, Hajizadeh R, Newman LS, Kalams SA
Infect Immun. 2007 75 (1): 527-30

PMID: 17088357 · PMCID: PMC1828402 · DOI:10.1128/IAI.00732-06

Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.

MeSH Terms (14)

Adult Antigens, Bacterial Bacterial Proteins Catalase Female Humans Leukocytes, Mononuclear Male Middle Aged Mycobacterium tuberculosis Sarcoidosis T-Lymphocytes Tuberculin Tuberculosis

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