Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors.

Balak MN, Gong Y, Riely GJ, Somwar R, Li AR, Zakowski MF, Chiang A, Yang G, Ouerfelli O, Kris MG, Ladanyi M, Miller VA, Pao W
Clin Cancer Res. 2006 12 (21): 6494-501

PMID: 17085664 · DOI:10.1158/1078-0432.CCR-06-1570

MeSH Terms (19)

Adenocarcinoma Amino Acid Sequence Antineoplastic Agents DNA Mutational Analysis Drug Resistance, Neoplasm ErbB Receptors Erlotinib Hydrochloride Gefitinib Gene Dosage Humans In Situ Hybridization Lung Neoplasms Molecular Sequence Data Mutation Neoplasm Metastasis Protein Kinase Inhibitors Protein Structure, Tertiary Quinazolines Reverse Transcriptase Polymerase Chain Reaction

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