The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.

Sánchez-Pedregal VM, Kubicek K, Meiler J, Lyothier I, Paterson I, Carlomagno T
Angew Chem Int Ed Engl. 2006 45 (44): 7388-94

PMID: 17036370 · DOI:10.1002/anie.200602793

MeSH Terms (11)

Alkanes Carbamates Epothilones Lactones Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Protein Binding Pyrones Solutions Tubulin

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