Urinary F2-isoprostane metabolite levels in children with sleep-disordered breathing.

Montgomery-Downs HE, Krishna J, Roberts LJ, Gozal D
Sleep Breath. 2006 10 (4): 211-5

PMID: 17028846 · DOI:10.1007/s11325-006-0079-5

Oxidant stress-related mechanisms have been proposed as a major contributor to the increased prevalence of cardiovascular morbidity in adult patients with sleep-disordered breathing. Isoprostanes provide a reliable biomarker of oxidant injury in vivo. The purpose of the present study was to examine the hypothesis that oxidant stress, as evidenced by increased levels of F2-isoprostane metabolites (IsoP-m) in urine, is present in children with a spectrum of sleep-disordered breathing. Assays were performed on urinary samples obtained from each of 47 pediatric patients immediately upon awakening after standard overnight polysomnography. Of the subjects, 15% had mild, 9% had moderate, and 6% had severe sleep-disordered breathing. After controlling for correlations between BMI and IsoP-m and SpO2 values, IsoP-m values were unrelated to any polysomnographic measures. The absence of increased levels of urinary F2-isoprostane metabolites in children with sleep-disordered breathing suggests that oxidative stress is not a significant feature of pediatric sleep-disordered breathing.

MeSH Terms (11)

Body Mass Index Child F2-Isoprostanes Female Humans Male Oxidative Stress Oxygen Polysomnography Reference Values Sleep Apnea Syndromes

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