DEP domains: More than just membrane anchors.

Chen S, Hamm HE
Dev Cell. 2006 11 (4): 436-8

PMID: 17011483 · DOI:10.1016/j.devcel.2006.09.011

The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.

MeSH Terms (9)

Models, Chemical Protein Binding Protein Structure, Tertiary Protein Subunits Receptors, G-Protein-Coupled RGS Proteins Saccharomyces cerevisiae Signal Transduction Substrate Specificity

Connections (1)

This publication is referenced by other Labnodes entities: