Genetic determination and correlation of body weight and body mass index (BMI) and cross-sectional geometric parameters of the femoral neck.

Xu H, Long JR, Yang YJ, Deng FY, Deng HW
Osteoporos Int. 2006 17 (11): 1602-7

PMID: 16951910 · DOI:10.1007/s00198-006-0141-y

INTRODUCTION - This study aimed to examine the genetic determination of body weight, body mass index (BMI) and cross-sectional geometric parameters of the femoral neck including cross-sectional area (CSA), cortical thickness (CT), sectional modulus (Z), and buckling ratio (BR), and to test the genetic correlation between body weight/BMI and the femoral neck geometric parameters.

METHODS - A total of 929 healthy subjects from 292 Chinese nuclear families was included. Femoral neck geometric parameters were estimated from bone mineral density (BMD) and bone area which were measured by dual energy X-ray absorptiometry (DXA).

RESULTS - The heritability (h(2)) estimate values were 0.643, 0.626, 0.626, 0.674, 0.405, and 0.615 for body weight, BMI, CSA, CT, Z, and BR, respectively. Body weight was significantly correlated with bone geometric parameters (p
CONCLUSION - In summary, our study suggested that body weight, BMI, and femoral neck geometry were under strong genetic determination. The strong genetic correlations suggested that the genetic factors of bone geometry may be overlapped with those of body weight and BMI.

MeSH Terms (13)

Absorptiometry, Photon Adult Aged Asian Continental Ancestry Group Body Mass Index Body Weight Bone Density Female Femur Neck Humans Male Middle Aged Phenotype

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