A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo.

Shoemaker AR, Oleksijew A, Bauch J, Belli BA, Borre T, Bruncko M, Deckwirth T, Frost DJ, Jarvis K, Joseph MK, Marsh K, McClellan W, Nellans H, Ng S, Nimmer P, O'Connor JM, Oltersdorf T, Qing W, Shen W, Stavropoulos J, Tahir SK, Wang B, Warner R, Zhang H, Fesik SW, Rosenberg SH, Elmore SW
Cancer Res. 2006 66 (17): 8731-9

PMID: 16951189 · DOI:10.1158/0008-5472.CAN-06-0367

MeSH Terms (18)

Aniline Compounds Animals Antineoplastic Agents bcl-X Protein Biphenyl Compounds Cell Line, Tumor Drug Synergism Humans Kinetics Lung Neoplasms Male Mice Mice, SCID Nitrophenols Paclitaxel Piperazines Sulfonamides Transplantation, Heterologous

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