Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice.

Ding M, Cui S, Li C, Jothy S, Haase V, Steer BM, Marsden PA, Pippin J, Shankland S, Rastaldi MP, Cohen CD, Kretzler M, Quaggin SE
Nat Med. 2006 12 (9): 1081-7

PMID: 16906157 · DOI:10.1038/nm1460

MeSH Terms (15)

Animals Basic Helix-Loop-Helix Transcription Factors Cell Proliferation Gene Expression Profiling Glomerulonephritis Humans Hypoxia-Inducible Factor 1, alpha Subunit Kidney Glomerulus Mice Mice, Knockout Mice, Transgenic Podocytes Receptors, CXCR4 Up-Regulation Von Hippel-Lindau Tumor Suppressor Protein

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