Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis.

Kash TL, Winder DG
Neuropharmacology. 2006 51 (5): 1013-22

PMID: 16904135 · DOI:10.1016/j.neuropharm.2006.06.011

Neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) have opposing effects on stress and anxiety. Both can modify synaptic activity through their binding to NPY receptors (YRs) and CRF receptors (CRFRs) respectively. The bed nucleus of the stria terminalis (BNST) is a brain region with enriched expression of both NPY and YRs and CRF and CRFRs. A component of the "extended amygdala", the BNST is anatomically well-situated to integrate stress and reward-related processing in the CNS, regulating activation of the hypothalamic-pituitary-adrenal (HPA) axis and reward circuits. Using whole-cell recordings in a BNST slice preparation, we found that NPY and CRF inhibit and enhance GABAergic transmission, respectively. Pharmacological experiments suggest that NPY depresses GABAergic transmission through activation of the Y2 receptor (Y2R), while both pharmacological and genetic experiments suggest that CRF and urocortin enhance GABAergic transmission through activation of the CRF receptor 1 (CRFR1). Further, the data suggest that NPY acts to regulate GABA release, while CRF enhances postsynaptic responses to GABA. These results suggest potential anatomical and cellular substrates for the robust behavioral interactions between NPY and CRF.

MeSH Terms (26)

Analysis of Variance Aniline Compounds Animals Corticotropin-Releasing Hormone Dose-Response Relationship, Radiation Drug Interactions Electric Stimulation Excitatory Postsynaptic Potentials GABA Antagonists gamma-Aminobutyric Acid Inhibitory Postsynaptic Potentials In Vitro Techniques Male Mice Mice, Inbred C57BL Mice, Knockout Neurons Neuropeptide Y Patch-Clamp Techniques Peptide Fragments Pyridazines Pyrimidines Receptors, Corticotropin-Releasing Hormone Septal Nuclei Synaptic Transmission Urocortins

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