Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.

Lindsley CW, Zhao Z, Leister WH, O'Brien J, Lemaire W, Williams DL, Chen TB, Chang RS, Burno M, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Tsou NN, Duggan ME, Conn PJ, Hartman GD
ChemMedChem. 2006 1 (8): 807-11

PMID: 16902933 · DOI:10.1002/cmdc.200600097

MeSH Terms (11)

Animals Antipsychotic Agents Benzamides Drug Design Glycine Plasma Membrane Transport Proteins Mice Mice, Inbred DBA Rats Schizophrenia Structure-Activity Relationship Sulfonamides

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