Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site.

Choi JY, Stover JS, Angel KC, Chowdhury G, Rizzo CJ, Guengerich FP
J Biol Chem. 2006 281 (35): 25297-306

PMID: 16835218 · DOI:10.1074/jbc.M605699200

MeSH Terms (13)

Biochemistry Deoxyribonucleases, Type II Site-Specific DNA DNA-Directed DNA Polymerase DNA Primers DNA Replication Gene Deletion Humans Kinetics Models, Chemical Quinolines Reproducibility of Results Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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