Oral contraceptive and IUD use and endometrial cancer: a population-based case-control study in Shanghai, China.

Tao MH, Xu WH, Zheng W, Zhang ZF, Gao YT, Ruan ZX, Cheng JR, Gao J, Xiang YB, Shu XO
Int J Cancer. 2006 119 (9): 2142-7

PMID: 16823853 · DOI:10.1002/ijc.22081

Oral contraceptive (OC) and intrauterine device (IUD) use have been shown to be protective factors for endometrial cancer in several epidemiological studies; however, few studies have been conducted in Chinese populations. We evaluated the association between OC and IUD use and endometrial cancer risk in a population-based case-control study among Chinese women in Shanghai, China. The study included 1,204 newly diagnosed endometrial cancer cases and 1,212 age frequency-matched healthy controls. Logistic regression models were used to estimate adjusted odds ratios (OR) and their 95% confidence intervals (95% CI). In our study population, 18.5% cases and 24.9% controls reported having ever used OCs with an OR of 0.75 (95% CI, 0.60-0.93), after adjusting for known risk or protective factors for endometrial cancer. The risk of endometrial cancer decreased with long-term use of OCs with the OR for more than 72 months of use being 0.50 (95% CI, 0.30-0.85). The effect of OC use remained 25 or more years after cessation of use; the associated OR was 0.57 (95% CI = 0.42-0.78) as compared to nonusers. Similarly, fewer cases than controls had ever used IUD, with the multivariable adjusted OR being 0.53 (95% CI = 0.43-0.65). A reduction in risk was observed regardless the duration of use or age at first and last use. These results suggest that OC and IUD use may confer long-term protection against endometrial cancer.

MeSH Terms (13)

Adult Case-Control Studies China Contraceptives, Oral Endometrial Neoplasms Female Humans Intrauterine Devices Middle Aged Risk Factors Smoking Socioeconomic Factors Time Factors

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