Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.

de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ
J Med Chem. 2006 49 (11): 3332-44

PMID: 16722652 · DOI:10.1021/jm051252j

MeSH Terms (20)

Allosteric Regulation Allosteric Site Animals Astrocytes Benzamides Binding, Competitive Binding Sites Calcium Cells, Cultured Cerebral Cortex Humans Oxadiazoles Piperidines Pyrazoles Quantitative Structure-Activity Relationship Radioligand Assay Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate

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